Soft materials possess several distinctive characteristics, such as controllable deformation,
infinite degrees of freedom, and self‐assembly, which make them promising candidates for …

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to
pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These …

Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering
technology that endows the somatic cell genome with totipotency. Since the first report on …

Abstract The National Institutes of Health (NIH) miniature pig was developed specifically for
xenotransplantation and has been extensively used as a large-animal model in many other …

Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell
research and regenerative medicine for the past 20 years. The main biological goal of SCNT …

Faulty epigenetic reprogramming of somatic nuclei is likely to be a major cause of low
success observed in all mammals produced through somatic cell nuclear transfer (SCNT). It …

It is now over a decade since the birth, in 1996, of Dolly the first animal to be produced by
nuclear transfer using an adult derived somatic cell as nuclear donor. Since this time similar …

Stem cells are characterized by their capability to self‐renew and terminally differentiate into
multiple cell types. Somatic or adult stem cells have a finite self‐renewal capacity and are …

Histone deacetylase inhibitors (HDACi) are small molecules that have important and
pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can …

The oocyte cytoplasm can reprogram the somatic cell nucleus into a totipotent state, but with
low efficiency. The spatiotemporal chromatin organization of somatic cell nuclear transfer …