Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Phosphatidylinositol lipids are signaling molecules involved in nearly all aspects of cellular
regulation. Production of phosphatidylinositol 4-phosphate (PI4P) has long been recognized …

Many RNA viruses remodel intracellular membranes to generate specialized sites for RNA
replication. How membranes are remodeled and what properties make them conducive for …

Abstract ADP ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and
membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine …

Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of
animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular …

Three Sec7 guanine nucleotide exchange factors (GEFs) activate ADP-ribosylation factors
(ARFs) to facilitate coating of transport vesicles within the secretory and endosomal …

The Sec7 domain ADP-ribosylation factor (Arf) guanine nucleotide exchange factors (GEFs)
are found in all eukaryotes, and are involved in membrane remodeling processes …

For the efficient trafficking of lysosomal proteins, the cationic‐dependent and‐independent
mannose 6‐phosphate receptors and sortilin must bind cargo in the Golgi apparatus, be …

The CLN3 gene was identified over two decades ago, but the primary function of the CLN3
protein remains unknown. Recessive inheritance of loss of function mutations in CLN3 are …

Eukaryotic cells require selective sorting and transport of cargo between intracellular
compartments. This is accomplished at least in part by vesicles that bud from a donor …