Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and
epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma …

Tumorigenesis has long been thought to be a multistep process (Foulds, 1958); however,
only recently has it become possible to identify the molecular events that underlie the …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Abstract Mutations in codon 12, 13, or 61 of one of the three ras genes, H-ras, K-ras, and N-
ras, convert these genes into active oncogenes. Rapid assays for the detection of these …

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

From the pioneering work with acute transforming retroviruses to the current post-genomic
era, RAS genes have always been at the leading edge of signal transduction and molecular …

Using in vitro gene amplification by the polymerase chain reaction (PCR) and mutation
detection by the RNAase A mismatch cleavage method, we have examined cK-ras genes in …

Previous studies have demonstrated that allelic deletions of the short arm of chromosome 17
occur in over 75% of colorectal carcinomas. Twenty chromosome 17p markers were used to …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …