Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
Using phecodes for research with the electronic health record: from PheWAS to PheRS
L Bastarache - Annual review of biomedical data science, 2021 - annualreviews.org
Electronic health records (EHRs) are a rich source of data for researchers, but extracting
meaningful information out of this highly complex data source is challenging. Phecodes …
meaningful information out of this highly complex data source is challenging. Phecodes …
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
[HTML][HTML] Mapping ICD-10 and ICD-10-CM codes to phecodes: workflow development and initial evaluation
Background: The phecode system was built upon the International Classification of
Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) for phenome-wide association …
Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) for phenome-wide association …
Polygenic prediction of preeclampsia and gestational hypertension
Preeclampsia and gestational hypertension are common pregnancy complications
associated with adverse maternal and child outcomes. Current tools for prediction …
associated with adverse maternal and child outcomes. Current tools for prediction …
Evolving phenotypes of non-hospitalized patients that indicate long COVID
Abstract Background For some SARS-CoV-2 survivors, recovery from the acute phase of the
infection has been grueling with lingering effects. Many of the symptoms characterized as …
infection has been grueling with lingering effects. Many of the symptoms characterized as …
Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank
Background The three main alleles of the APOE gene (ε4, ε3 and ε2) carry differential risks
for conditions including Alzheimer's disease (AD) and cardiovascular disease. Due to their …
for conditions including Alzheimer's disease (AD) and cardiovascular disease. Due to their …
Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
TG Brooks, NF Lahens, GR Grant, YI Sheline… - Nature …, 2023 - nature.com
Many chronic disease symptomatologies involve desynchronized sleep-wake cycles,
indicative of disrupted biorhythms. This can be interrogated using body temperature …
indicative of disrupted biorhythms. This can be interrogated using body temperature …
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
Learning from longitudinal data in electronic health record and genetic data to improve cardiovascular event prediction
Current approaches to predicting a cardiovascular disease (CVD) event rely on
conventional risk factors and cross-sectional data. In this study, we applied machine …
conventional risk factors and cross-sectional data. In this study, we applied machine …