Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic
cell death. The conversion of methionine to cysteine is well known to protect tumour cells …

Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Autophagy is a catabolic process that facilitates nutrient recycling via degradation of
damaged organelles and proteins through lysosomal mediated degradation. Alterations in …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four
decades ago, much effort has been made to uncover the molecular mechanisms underlying …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …