Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

INTRODUCTION Canonical inflammasomes are multicomponent protein complexes that
play key roles in immune surveillance of infections and danger by activating caspase-1 …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

Among the different types of cytoskeletal components, microtubules arguably accumulate
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Histone deacetylase 6 (HDAC6) primarily catalyzes the removal of acetyl group from the
side chain of acetylated lysine residues in cytoplasmic proteins such as α-tubulin and …

Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Liquid–liquid phase separation (LLPS) of proteins containing intrinsically disordered regions
(IDRs) has been proposed as a mechanism underlying the formation of membrane-less …

Cationic polyamines such as spermidine and spermine are critical in all forms of life, as they
regulate the function of biological macromolecules. Intracellular polyamine metabolism is …