Theoretical perspectives on biological machines
Many biological functions are executed by molecular machines, which like man-made
motors are powered by chemical energy, released by adenosine triphosphate hydrolysis …
motors are powered by chemical energy, released by adenosine triphosphate hydrolysis …
Probing the allosteric inhibition mechanism of a spike protein using molecular dynamics simulations and active compound identifications
Q Wang, L Wang, Y Zhang, XL Zhang… - Journal of Medicinal …, 2021 - ACS Publications
The receptor recognition of the novel coronavirus SARS-CoV-2 relies on the “down-to-up”
conformational change in the receptor-binding domain (RBD) of the spike (S) protein …
conformational change in the receptor-binding domain (RBD) of the spike (S) protein …
Computational modeling of dynein motor proteins at work
Along with various experimental methods, a combination of theoretical and computational
methods is essential to explore different length-scale and time-scale processes in the …
methods is essential to explore different length-scale and time-scale processes in the …
Regulatory mechanisms of the dynein-2 motility by post-translational modification revealed by MD simulation
Intraflagellar transport for ciliary assembly and maintenance is driven by dynein and
kinesins specific to the cilia. It has been shown that anterograde and retrograde transports …
kinesins specific to the cilia. It has been shown that anterograde and retrograde transports …
Self-organized networks: Darwinian evolution of dynein rings, stalks, and stalk heads
JC Phillips - Proceedings of the National Academy of …, 2020 - National Acad Sciences
Cytoskeletons are self-organized networks based on polymerized proteins: actin, tubulin,
and driven by motor proteins, such as myosin, kinesin, and dynein. Their positive Darwinian …
and driven by motor proteins, such as myosin, kinesin, and dynein. Their positive Darwinian …
Moving in the mesoscale: Understanding the mechanics of cytoskeletal molecular motors by combining mesoscale simulations with imaging
MSC Gravett, RC Cocking, AP Curd… - Wiley …, 2022 - Wiley Online Library
Rapid advances in experimental biophysical techniques are generating a wealth of
information about the mechanical operation of the cellular cytoskeleton and its motors …
information about the mechanical operation of the cellular cytoskeleton and its motors …
Mechanistic basis of propofol-induced disruption of kinesin processivity
Propofol is a widely used general anesthetic to induce and maintain anesthesia, and its
effects are thought to occur through impact on the ligand-gated channels including the …
effects are thought to occur through impact on the ligand-gated channels including the …
How cytoplasmic dynein couples ATP hydrolysis cycle to diverse stepping motions: kinetic modeling
Cytoplasmic dynein is a two-headed molecular motor that moves to the minus end of a
microtubule by ATP hydrolysis free energy. By employing its two heads (motor domains) …
microtubule by ATP hydrolysis free energy. By employing its two heads (motor domains) …
Effect of flagellar beating pattern on sperm rheotaxis and boundary-dependent navigation
The study of navigational mechanisms used by mammalian sperm inside a
microenvironment yields better understanding of sperm locomotion during the insemination …
microenvironment yields better understanding of sperm locomotion during the insemination …
Key residue on cytoplasmic dynein for asymmetric unbinding and unidirectional movement along microtubule
Cytoplasmic dynein 1 is almost exclusively responsible for intracellular transport toward the
minus-end of microtubules in animal cells. One of the key factors for the unidirectional …
minus-end of microtubules in animal cells. One of the key factors for the unidirectional …