Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

A critical step during human microRNA maturation is the processing of the primary
microRNA transcript by the nuclear RNaseIII enzyme Drosha to generate the∼ 60 …

H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

Abstract H2A. Z is an essential histone variant implicated in the regulation of key nuclear
events. However, the metazoan chaperones responsible for H2A. Z deposition and its …

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional
regulation locally and globally via modifications of the DNA and by modification or …