Mitochondrial movers and shapers: recent insights into regulators of fission, fusion and transport

NU Fatima, V Ananthanarayanan - Current Opinion in Cell Biology, 2023 - Elsevier
Mitochondria are highly dynamic organelles that undergo rapid morphological adaptations
influencing their number, transport, cellular distribution, and function, which in turn facilitate …

Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease

H Verma, P Gangwar, A Yadav, B Yadav, R Rao… - Mitochondrion, 2023 - Elsevier
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …

[HTML][HTML] Microtubule-based mitochondrial dynamics as a valuable therapeutic target in cancer

R Vona, AM Mileo, P Matarrese - Cancers, 2021 - mdpi.com
Simple Summary Mitochondria are well known for being the powerhouses of the cell—
whether the cell is normal or cancerous. Moreover, they can move, split, fuse themselves, or …

[HTML][HTML] Mitophagy and neurodegeneration: between the knowns and the unknowns

CT Jetto, A Nambiar, R Manjithaya - Frontiers in cell and …, 2022 - frontiersin.org
Macroautophagy (henceforth autophagy) an evolutionary conserved intracellular pathway,
involves lysosomal degradation of damaged and superfluous cytosolic contents to maintain …

[HTML][HTML] Mitochondrial determinants of anti-cancer drug-induced cardiotoxicity

C Rocca, EM De Francesco, T Pasqua, MC Granieri… - Biomedicines, 2022 - mdpi.com
Mitochondria are key organelles for the maintenance of myocardial tissue homeostasis,
playing a pivotal role in adenosine triphosphate (ATP) production, calcium signaling, redox …

[HTML][HTML] Mitochondrial cellular organization and shape fluctuations are differentially modulated by cytoskeletal networks

AB Fernández Casafuz, MC De Rossi, L Bruno - Scientific Reports, 2023 - nature.com
The interactions between mitochondria and the cytoskeleton have been found to alter
mitochondrial function; however, the mechanisms underlying this phenomenon are largely …

[HTML][HTML] Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases

J Li, X Li, S Song, Z Sun, Y Li, L Yang, Z Xie, Y Cai… - Redox Biology, 2023 - Elsevier
Cardiovascular diseases caused by atherosclerosis (AS) seriously endanger human health,
which is closely related to vascular smooth muscle cell (VSMC) phenotypes. VSMC …

[HTML][HTML] Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

K Zhang, E Yao, B Chen, E Chuang, J Wong, RI Seed… - Elife, 2022 - ncbi.nlm.nih.gov
Alveolar formation requires coordinated movement and interaction between alveolar
epithelial cells, mesenchymal myofibroblasts, and endothelial cells/pericytes to produce …

[HTML][HTML] Advances in cardiotoxicity induced by altered mitochondrial dynamics and mitophagy

Y Yin, H Shen - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Mitochondria are the most abundant organelles in cardiac cells, and are essential to
maintain the normal cardiac function, which requires mitochondrial dynamics and mitophagy …

[HTML][HTML] Targeting deubiquitinating enzymes (DUBs) that regulate mitophagy via direct or indirect interaction with Parkin

E Tsefou, R Ketteler - International Journal of Molecular Sciences, 2022 - mdpi.com
The quality control of mitochondria is critical for the survival of cells, and defects in the
pathways required for this quality control can lead to severe disease. A key quality control …