Bone regeneration is very important for the recovery of some diseases including
osteoporosis and bone fracture trauma. It is a multiple‐step‐and multiple‐gene‐involved …

With the development of RNA modification research, the importance of N6-methyladenosine
(m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Mechanical unloading leads to bone loss and disuse osteoporosis partly due to impaired
osteoblastogenesis of bone marrow stromal cells (BMSCs). However, the underlying …

Histone modifications are important for maintaining the transcription program. BET proteins,
an important class of “histone reading proteins”, have recently been described as essential …

Thus far, there are more than known 150 modifications to RNA, in which common internal
modifications of mRNA include N6-methyladenosine (m6A), N1-methyladenosine, and 5 …

Abstract Bromodomain 4 (BRD4), an important epigenetic regulator, is involved in many
bone-related pathologies via promoting osteoclast formation. However, whether and how it …

Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public
health problem. Osteogenic differentiation is a complex process associated with the …

Spinal cord injury is a devastating disease which disrupts the connections between the brain
and spinal cord, often resulting in the loss of sensory and motor function below the lesion …

MicroRNAs (miRNAs) are novel key regulators of cellular differentiation. miR-124 has been
reported to regulate osteogenic differentiation of bone marrow-derived mesenchymal stem …