The neural circuitry that mediates mood under normal and abnormal conditions remains
incompletely understood. Most attention in the field has focused on hippocampal and frontal …

Multiple sources of evidence support a role for diminished dopaminergic neurotrans-mission
in major depression. The physiological alterations underlying reduced dopa-mine (DA) …

The past several years have seen a resurgence of interest in understanding the
psychological and neural bases of what are often referred to as “negative symptoms” in …

Neurotransmitters are chemicals that are secreted by neurons and relay messages to target
cells. The goal of in vivo electrochemistry is to provide a real-time view of neurotransmitters …

The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in
motivated behaviors, various types of reward, and, more recently, in cognitive processes …

From Aaron T. Beck and colleagues, this is the definitive work on the cognitive model of
schizophrenia and its treatment. The volume integrates cognitive-behavioral and biological …

Levodopa-induced motor complications are a common source of disability for patients with
Parkinson's disease. Evidence suggests that motor complications are associated with non …

Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this
link remains unclear, it may be potentially related to the partial congruence of physical and …

Rationale Animal research suggests that anticipation of reward can elicit dopamine release
in the nucleus accumbens (NAcc). Human functional magnetic resonance imaging (FMRI) …

Background and objectives The idea that nucleus accumbens (Acb) dopamine transmission
contributes to the neural mediation of reward, at least in a general sense, has achieved wide …