Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

[HTML][HTML] Oral candidiasis: A disease of opportunity

T Vila, AS Sultan, D Montelongo-Jauregui… - Journal of fungi, 2020 - mdpi.com
Oral candidiasis, commonly referred to as “thrush,” is an opportunistic fungal infection that
commonly affects the oral mucosa. The main causative agent, Candida albicans, is a highly …

Development and regulation of single- and multi-species Candida albicans biofilms

MB Lohse, M Gulati, AD Johnson… - Nature Reviews …, 2018 - nature.com
Candida albicans is among the most prevalent fungal species of the human microbiota and
asymptomatically colonizes healthy individuals. However, it is also an opportunistic …

[HTML][HTML] Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis

D Lin, L Yang, L Wen, H Lu, Q Chen, Z Wang - Mucosal immunology, 2021 - Elsevier
Oral mucosal disease (OMD), which is also called soft tissue oral disease, is described as a
series of disorders or conditions affecting the mucosa and soft tissue in the oral cavity. Its …

[HTML][HTML] Candidalysin: discovery and function in Candida albicans infections

JR Naglik, SL Gaffen, B Hube - Current opinion in microbiology, 2019 - Elsevier
Highlights•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•
Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin …

[HTML][HTML] Oral candidosis: pathophysiology and best practice for diagnosis, classification, and successful management

SY Lu - Journal of Fungi, 2021 - mdpi.com
Oral candidosis is the most common fungal infection that frequently occurs in patients
debilitated by other diseases or conditions. No candidosis happens without a cause; hence …

[HTML][HTML] Immunosurveillance of Candida albicans commensalism by the adaptive immune system

M Swidergall, S LeibundGut-Landmann - Mucosal immunology, 2022 - Elsevier
The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing
the body surfaces and is involved in many key aspects of human physiology, while an …

EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans

M Swidergall, NV Solis, MS Lionakis, SG Filler - Nature microbiology, 2018 - nature.com
Oral epithelial cells discriminate between pathogenic and non-pathogenic stimuli, and only
induce an inflammatory response when they are exposed to high levels of a potentially …

Oral epithelial IL-22/STAT3 signaling licenses IL-17–mediated immunity to oral mucosal candidiasis

FEY Aggor, TJ Break, G Trevejo-Nuñez… - Science …, 2020 - science.org
Oropharyngeal candidiasis (OPC; thrush) is an opportunistic infection caused by the
commensal fungus Candida albicans. Interleukin-17 (IL-17) and IL-22 are cytokines …

IκBζ is an essential mediator of immunity to oropharyngeal candidiasis

TC Taylor, BM Coleman, SP Arunkumar, I Dey… - Cell Host & Microbe, 2023 - cell.com
Fungal infections are a global threat; yet, there are no licensed vaccines to any fungal
pathogens. Th17 cells mediate immunity to Candida albicans, particularly oropharyngeal …