Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …

The global burden of obesity has multiplied owing to its rapidly growing prevalence and
obesity-related morbidity and mortality. In addition to the classic role of depositing extra …

Background Inflammation and fibrosis play an important role in the pathogenesis of atrial
fibrillation (AF) after myocardial infarction (MI). CTRP9 (C1q/tumor necrosis factor‐related …

Hyperglycemia-induced endothelial cell senescence has been widely reported to be
involved in the pathogenesis of type 2 diabetes mellitus‒accelerated atherosclerosis. Thus …

Background Ischemic heart diseases and ischemic stroke are closely related to circadian
clock and unstable atherosclerotic plaques. Vascular smooth muscle cells (VSMCs) can …

Cardiokines play an essential role in maintaining normal cardiac functions and responding
to acute myocardial injury. Studies have demonstrated the heart itself is a significant source …

The timely regulation of inflammatory M1 macrophage polarization toward regenerative M2
macrophages suggests the possibility of immunotherapy after myocardial infarction (MI) …

Hydrogen sulfide (H2S) is one of most important gas transmitters. H2S modulates many
physiological and pathological processes such as inflammation, oxidative stress and cell …

During the pathogenesis of early atherosclerosis, lipid-loaded macrophages are involved in
plaque development and progression. As a novel adipokine, C1q/tumor necrosis factor …

C1q tumor necrosis factor-related protein 9 (CTRP9), a newly discovered adipokine, is the
closest paralog of adiponectin. After proteolytic cleavage, it can release the globular domain …