Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria
SM Zeiders, J Chmielewski - Chemical biology & drug design, 2021 - Wiley Online Library
The failure to treat everyday bacterial infections is a current threat as pathogens are finding
new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge …
new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge …
Mitochondrion-targeting peptides and peptidomimetics: recent progress and design principles
Mitochondria are multifunctional subcellular organelles whose operations encompass
energy production, signal transduction, and metabolic regulation. Given their wide range of …
energy production, signal transduction, and metabolic regulation. Given their wide range of …
Targeting intracellular, multi-drug resistant Staphylococcus aureus with guanidinium polymers by elucidating the structure-activity relationship
Intracellular persistence of bacteria represents a clinical challenge as bacteria can thrive in
an environment protected from antibiotics and immune responses. Novel targeting strategies …
an environment protected from antibiotics and immune responses. Novel targeting strategies …
[HTML][HTML] Cell-penetrating antimicrobial peptides with anti-infective activity against intracellular pathogens
GS Cruz, AT Santos, EHS Brito, G Radis-Baptista - Antibiotics, 2022 - mdpi.com
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the
intrinsic ability to internalize into a diversity of cell types and simultaneously transport …
intrinsic ability to internalize into a diversity of cell types and simultaneously transport …
[HTML][HTML] Anticipating alien cells with alternative genetic codes: away from the alanine world!
V Kubyshkin, N Budisa - Current opinion in biotechnology, 2019 - Elsevier
Highlights•To change the genetic code, we need to understand how it was originally
set.•The amino acid repertoire of the genetic code consists mainly of derivatives of …
set.•The amino acid repertoire of the genetic code consists mainly of derivatives of …
Induction of Endogenous Antibody Recruitment to the Surface of the Pathogen Enterococcus faecium
BE Dalesandro, MM Pires - ACS infectious diseases, 2020 - ACS Publications
For the foreseeable future, conventional small molecule antibiotics will continue to be the
predominant treatment option due to wide patient coverage and low costs. Today, however …
predominant treatment option due to wide patient coverage and low costs. Today, however …
[HTML][HTML] Intracellular bactericidal activity and action mechanism of MDP1 antimicrobial peptide against VRSA and MRSA in human endothelial cells
Introduction Staphylococcus aureus is a prominent cause of postoperative infections, often
persisting within host cells, leading to chronic infections. Conventional antibiotics struggle to …
persisting within host cells, leading to chronic infections. Conventional antibiotics struggle to …
Effects of Rigidity and Configuration of Charged Moieties within Cationic Amphiphilic Polyproline Helices on Cell Penetration and Antibiotic Activity
A Encinas, R Blade, NS Abutaleb… - ACS Infectious …, 2024 - ACS Publications
Effective molecular strategies are needed to target pathogenic bacteria that thrive and
proliferate within mammalian cells, a sanctuary inaccessible to many therapeutics. Herein …
proliferate within mammalian cells, a sanctuary inaccessible to many therapeutics. Herein …
Targeting intracellular pathogenic bacteria through n-terminal modification of cationic amphiphilic polyproline helices
TA Dietsche, HE Eldesouky, SM Zeiders… - The Journal of …, 2020 - ACS Publications
Intracellular pathogens can thrive within mammalian cells and are inaccessible to many
antimicrobial agents. Herein, we present a facile method of enhancing the cell penetrating …
antimicrobial agents. Herein, we present a facile method of enhancing the cell penetrating …
Multivalent display of chemical signals on self‐assembled peptide scaffolds
HE Distaffen, CW Jones, BL Abraham… - Peptide …, 2021 - Wiley Online Library
Self‐assembled peptide materials have emerged as promising bioinspired tools for
applications that include regenerative medicine, drug delivery, antimicrobial and vaccine …
applications that include regenerative medicine, drug delivery, antimicrobial and vaccine …