Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria

SM Zeiders, J Chmielewski - Chemical biology & drug design, 2021 - Wiley Online Library
The failure to treat everyday bacterial infections is a current threat as pathogens are finding
new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge …

Mitochondrion-targeting peptides and peptidomimetics: recent progress and design principles

S Kim, HY Nam, J Lee, J Seo - Biochemistry, 2019 - ACS Publications
Mitochondria are multifunctional subcellular organelles whose operations encompass
energy production, signal transduction, and metabolic regulation. Given their wide range of …

Targeting intracellular, multi-drug resistant Staphylococcus aureus with guanidinium polymers by elucidating the structure-activity relationship

A Kuroki, AK Tchoupa, M Hartlieb, R Peltier… - Biomaterials, 2019 - Elsevier
Intracellular persistence of bacteria represents a clinical challenge as bacteria can thrive in
an environment protected from antibiotics and immune responses. Novel targeting strategies …

[HTML][HTML] Cell-penetrating antimicrobial peptides with anti-infective activity against intracellular pathogens

GS Cruz, AT Santos, EHS Brito, G Radis-Baptista - Antibiotics, 2022 - mdpi.com
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the
intrinsic ability to internalize into a diversity of cell types and simultaneously transport …

[HTML][HTML] Anticipating alien cells with alternative genetic codes: away from the alanine world!

V Kubyshkin, N Budisa - Current opinion in biotechnology, 2019 - Elsevier
Highlights•To change the genetic code, we need to understand how it was originally
set.•The amino acid repertoire of the genetic code consists mainly of derivatives of …

Induction of Endogenous Antibody Recruitment to the Surface of the Pathogen Enterococcus faecium

BE Dalesandro, MM Pires - ACS infectious diseases, 2020 - ACS Publications
For the foreseeable future, conventional small molecule antibiotics will continue to be the
predominant treatment option due to wide patient coverage and low costs. Today, however …

[HTML][HTML] Intracellular bactericidal activity and action mechanism of MDP1 antimicrobial peptide against VRSA and MRSA in human endothelial cells

S Dashtbin, S Razavi, M Ganjali Koli, F Barneh… - Frontiers in …, 2024 - frontiersin.org
Introduction Staphylococcus aureus is a prominent cause of postoperative infections, often
persisting within host cells, leading to chronic infections. Conventional antibiotics struggle to …

Effects of Rigidity and Configuration of Charged Moieties within Cationic Amphiphilic Polyproline Helices on Cell Penetration and Antibiotic Activity

A Encinas, R Blade, NS Abutaleb… - ACS Infectious …, 2024 - ACS Publications
Effective molecular strategies are needed to target pathogenic bacteria that thrive and
proliferate within mammalian cells, a sanctuary inaccessible to many therapeutics. Herein …

Targeting intracellular pathogenic bacteria through n-terminal modification of cationic amphiphilic polyproline helices

TA Dietsche, HE Eldesouky, SM Zeiders… - The Journal of …, 2020 - ACS Publications
Intracellular pathogens can thrive within mammalian cells and are inaccessible to many
antimicrobial agents. Herein, we present a facile method of enhancing the cell penetrating …

Multivalent display of chemical signals on self‐assembled peptide scaffolds

HE Distaffen, CW Jones, BL Abraham… - Peptide …, 2021 - Wiley Online Library
Self‐assembled peptide materials have emerged as promising bioinspired tools for
applications that include regenerative medicine, drug delivery, antimicrobial and vaccine …