ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Background Taxanes, including paclitaxel and docetaxel, are indispensable for treatment of
cancer. Development of toxicity frequently necessitates dose reduction or discontinuation of …

Abstract Cytochrome 450 (CYP450) designates a group of enzymes abundant in smooth
endoplasmic reticulum of hepatocytes and epithelial cells of small intestines. The main …

Breast cancer (BC) is one of the most prevalent types of cancer worldwide with high
morbidity and mortality rates. Treatment modalities include systemic therapy, in which …

The differences in patients' response to the same medication, toxicity included, are one of
the major problems in breast cancer treatment. Chemotherapy toxicity makes a significant …

Colorectal cancer (CRC) is one of the most aggressive cancers worldwide. Several
anticancer agents are available to treat CRC, but eventually cancer relapse occurs. One …

The ABCB1 gene encodes a permeability glycoprotein, which is one of the most extensively
studied human adenosine-triphosphate (ATP)-dependent efflux transporters. Permeability …

Purpose: Docetaxel is extensively metabolized by CYP3A4 in the liver but mechanisms by
which the drug is taken up into hepatocytes remain poorly understood. We hypothesized that …

In the “precision medicine” era, chemotherapy still remains the backbone for the treatment of
many cancers, but no affordable predictors of response to the chemodrugs are available in …

Interindividual variability in drug response and the emergence of adverse drug effects are
the main causes of treatment failure in cancer therapy. Functional membrane drug …