Complex living systems are thought to exist at the “edge of chaos” separating the ordered
dynamics of robust function from the disordered dynamics of rapid environmental …

Gene regulatory networks (GRNs) play a central role in cellular decision-making.
Understanding their structure and how it impacts their dynamics constitutes thus a …

The adoption of digital twins (DTs) in precision medicine is increasingly viable, propelled by
extensive data collection and advancements in artificial intelligence (AI), alongside …

Interaction relationships are fundamental to the behavior of complex systems. This study,
grounded in Boolean discrete systems, conducts a comprehensive investigation of ordered …

There has recently been an explosion of interest in how “higher-order” structures emerge in
complex systems comprised of many interacting elements (often called “synergistic” …

A common feature of complex systems is their ability to balance the flexibility needed to
adapt to their environment with the rigidity required for robust function. It has been …

The biomolecular networks underpinning cell function exhibit canalization, or the buffering of
fluctuations required to function in a noisy environment. One understudied putative …

Abstract Finite-State Dynamics (FSD) is one of the simplest and constrained distributed
systems. An FSD is defined by an n-node network, with each node maintaining an internal …