Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular
processes in neurons, the dysregulation of which compromises normal brain function. The …

Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a
crucial regulator of neuronal migration in the developing central nervous system. CDK5 …

Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various
neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of …

Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological
events in Alzheimer's disease (AD) and other related neurodegenerative diseases, including …

Abstract Cyclin-dependent kinase 5 (Cdk5) and its regulatory subunit p35 are integral
players in the proper development of the mammalian central nervous system. Proteolytic …

The adult mammalian cortex is characterized by a distinct laminar structure generated
through a well-defined pattern of neuronal migration. Successively generated neurons are …

ABSTRACT Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent
kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is …

Considerable effort has gone into understanding the mechanisms underlying high-
frequency'bursting'of thalamocortical impulses, their sensory information content and their …

Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/threonine kinase protein with
important roles in the nervous system. Two related proteins, p35 and p39, activate Cdk5 …

Formation of the mammalian brain requires choreographed migration of neurons to
generate highly ordered laminar structures such as those in the cortices of the forebrain and …