Vaccines, reverse vaccinology, and bacterial pathogenesis
I Delany, R Rappuoli, KL Seib - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Advances in genomics and innovative strategies such as reverse vaccinology have changed
the concepts and approaches to vaccine candidate selection and design. Genome mining …
the concepts and approaches to vaccine candidate selection and design. Genome mining …
Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease
LK McNeil, RJ Zagursky, SL Lin, E Murphy… - Microbiology and …, 2013 - Am Soc Microbiol
Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans
and can cause devastating invasive disease. Although capsular polysaccharide-based …
and can cause devastating invasive disease. Although capsular polysaccharide-based …
Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: a randomised, single …
Background Neisseria meningitidis serogroup B is a major cause of invasive meningococcal
disease, but a broadly protective vaccine is not currently licensed. A bivalent recombinant …
disease, but a broadly protective vaccine is not currently licensed. A bivalent recombinant …
Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen
E Malito, A Faleri, P Lo Surdo… - Proceedings of the …, 2013 - National Acad Sciences
Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for
understanding the nature of immune responses and designing improved vaccines …
understanding the nature of immune responses and designing improved vaccines …
A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination
PT Beernink, J Shaughnessy, EM Braga… - The Journal of …, 2011 - journals.aai.org
Certain pathogens recruit host complement inhibitors such as factor H (fH) to evade the
immune system. Microbial complement inhibitor-binding molecules can be promising …
immune system. Microbial complement inhibitor-binding molecules can be promising …
The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on …
LA Lewis, M Carter, S Ram - The Journal of Immunology, 2012 - journals.aai.org
Neisseria meningitidis inhibits the alternative pathway (AP) of complement using diverse
mechanisms, including expression of capsule (select serogroups), Neisserial surface protein …
mechanisms, including expression of capsule (select serogroups), Neisserial surface protein …
Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis
LA Lewis, DM Vu, S Vasudhev, J Shaughnessy… - MBio, 2013 - Am Soc Microbiol
The identification of “factor H binding protein (fHbp)-null” invasive meningococcal isolates
and the realization that widespread use of fHbp-based vaccines could herald selection of …
and the realization that widespread use of fHbp-based vaccines could herald selection of …
An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands
S Bambini, J Piet, A Muzzi, W Keijzers, S Comandi… - PloS one, 2013 - journals.plos.org
Studies of meningococcal evolution and genetic population structure, including the long-
term stability of non-random associations between variants of surface proteins, are essential …
term stability of non-random associations between variants of surface proteins, are essential …
Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce …
KL Seib, B Brunelli, B Brogioni, E Palumbo… - Infection and …, 2011 - Am Soc Microbiol
Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause
of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds …
of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds …
Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding
S Giuntini, DC Reason, DM Granoff - Infection and immunity, 2011 - Am Soc Microbiol
Binding of the complement-downregulating protein factor H (fH) to the surface of the
meningococcus is important for survival of the organism in human serum. The …
meningococcus is important for survival of the organism in human serum. The …