Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

Periodontitis and osteoporosis are prevalent inflammation‐associated skeletal disorders that
pose significant public health challenges to our aging population. Both periodontitis and …

An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …

Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Bone fractures are the most common traumatic injuries in humans. The repair of bone
fractures is a regenerative process that recapitulates many of the biological events of …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Bone consists of separate inner endosteal and outer periosteal compartments, each with
distinct contributions to bone physiology and each maintaining separate pools of cells owing …

The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …