The concept of chelation therapy as a valuable therapeutic approach in neurological
disorders led us to develop multi-target, non-toxic, lipophilic, brain-permeable compounds …

Traumatic injury of the central nervous system is one of the leading causes of death and
disability in young adults. Failure of regeneration is caused by autonomous neuronal …

Fluorescence microscopy allows for the high-throughput imaging of cellular activity across
brain areas in mammals. However, capturing rapid cellular dynamics across the curved …

There is a strong demand for techniques that allow the fabrication of biocompatible porous
nanoparticles for drug delivery applications. In this work, a new method to fabricate size‐and …

Alpha-motoneurons appear to be exceedingly affected in neurodegenerative diseases such
as amyotrophic lateral sclerosis (ALS). Morphological and physiological degeneration of this …

Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological signature of
amyotrophic lateral sclerosis (ALS). Although accumulating evidence suggests the …

Novel therapeutic approaches for the treatment of neurodegenerative disorders comprise
drug candidates designed specifically to act on multiple central nervous system targets. We …

Telomerase is expressed in the neonatal brain, in distinct regions of adult brain, and was
shown to protect developing neurons from apoptosis. Telomerase reactivation by gene …

Recent studies have implicated enhanced Nox2-mediated reactive oxygen species (ROS)
by microglia in the pathogenesis of motor neuron death observed in familial amyotrophic …

Spinal muscular atrophy (SMA) is characterized by the selective loss of spinal motor
neurons owing to reduced levels of survival motor neuron (Smn) protein. In addition to its …