The role of mitochondria in insulin resistance and type 2 diabetes mellitus
J Szendroedi, E Phielix, M Roden - Nature Reviews Endocrinology, 2012 - nature.com
Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …
Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle
CGR Perry, J Lally, GP Holloway… - The Journal of …, 2010 - Wiley Online Library
Exercise training induces mitochondrial biogenesis, but the time course of molecular
sequelae that accompany repetitive training stimuli remains to be determined in human …
sequelae that accompany repetitive training stimuli remains to be determined in human …
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
G Haemmerle, T Moustafa, G Woelkart, S Büttner… - Nature medicine, 2011 - nature.com
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
regulate genes involved in energy metabolism and inflammation. For biological activity …
regulate genes involved in energy metabolism and inflammation. For biological activity …
Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury
L Wang, N Quan, W Sun, X Chen, C Cates… - Cardiovascular …, 2018 - academic.oup.com
Aims A longevity gene, Sirtuin 1 (SIRT1) and energy sensor AMP-activated protein kinase
(AMPK) have common activators such as caloric restriction, oxidative stress, and exercise …
(AMPK) have common activators such as caloric restriction, oxidative stress, and exercise …
Skeletal Muscle Mitochondria in Insulin Resistance: Differences in Intermyofibrillar Versus Subsarcolemmal Subpopulations and Relationship to Metabolic Flexibility
P Chomentowski, PM Coen, Z Radikova… - The Journal of …, 2011 - academic.oup.com
abstract Context: Insulin resistance is accompanied by lower lipid oxidation during fasting
and metabolic inflexibility. Whether these abnormalities correlate with mitochondrial content …
and metabolic inflexibility. Whether these abnormalities correlate with mitochondrial content …
[HTML][HTML] Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism
A novel stress-inducible protein, Sestrin2 (Sesn2), declines in the heart with aging. AMPK
has emerged as a pertinent stress-activated kinase that has been shown to have …
has emerged as a pertinent stress-activated kinase that has been shown to have …
Sex differences in mitochondrial respiratory function in human skeletal muscle
Mitochondrial bioenergetic contributions to sex differences in human skeletal muscle
metabolism remain poorly defined. The primary aim of this study was to determine whether …
metabolism remain poorly defined. The primary aim of this study was to determine whether …
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway
N Quan, L Wang, X Chen, C Luckett, C Cates… - Journal of molecular and …, 2018 - Elsevier
We have revealed that a novel stress-inducible protein, Sestrin2, declines in the heart with
aging. Moreover, there is an interaction between Sestrin2 and energy sensor AMPK in the …
aging. Moreover, there is an interaction between Sestrin2 and energy sensor AMPK in the …
Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in …
CR Benton, GP Holloway, XX Han, Y Yoshida… - Diabetologia, 2010 - Springer
Aims/hypothesis Reductions in peroxisome proliferator-activated receptor gamma,
coactivator 1 alpha (PGC-1α) levels have been associated with the skeletal muscle insulin …
coactivator 1 alpha (PGC-1α) levels have been associated with the skeletal muscle insulin …