The use of consensus design to produce stable proteins has been applied to numerous
structures and classes of proteins. Here, we describe the engineering of novel FN3 domains …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Histone tails and their epigenetic modifications play crucial roles in gene expression
regulation by altering the architecture of chromatin. However, the structural mechanisms by …

Nearly 30% of human proteins have tandem repeating sequences. Structural understanding
of the terminal repeats is well-established for many repeat proteins with the common α-helix …

Collagen, a vital protein that provides strength to various body tissues, has a triple helix
structure containing three polypeptide chains. The chains are composed mostly of a …

Hsp70 3 molecular chaperones play key roles in cellular protein homeostasis by binding to
exposed hydrophobic regions of incompletely folded or aggregated proteins. This crucial …

Background Existing methods for predicting protein solubility on overexpression in
Escherichia coli advance performance by using ensemble classifiers such as two-stage …

The beta hairpin motif is a ubiquitous protein structural motif that can be found in molecules
across the tree of life. This motif, which is also popular in synthetically designed proteins and …

Some spiders aerially disperse relying on their fine fibres. This behaviour has been known
as 'ballooning'. Observations on the ballooning behaviour of spiders have a long history and …

Background Despite the importance of β-strands as main building blocks in proteins, the
propensity of amino acid in β-strands is not well-understood as it has been more difficult to …