[HTML][HTML] Arylmethylene hydrazine derivatives containing 1, 3-dimethylbarbituric moiety as novel urease inhibitors
A new series of arylmethylene hydrazine derivatives bearing 1, 3-dimethylbarbituric moiety
7a–o were designed, synthesized, and evaluated for their in vitro urease inhibitory activity …
7a–o were designed, synthesized, and evaluated for their in vitro urease inhibitory activity …
[HTML][HTML] Synthesis and investigation of anti-inflammatory activity of new thiourea derivatives of naproxen
N Nedeljković, V Dobričić, J Bošković, M Vesović… - Pharmaceuticals, 2023 - mdpi.com
The aim of the study was a synthesis and investigation of the dose-dependent anti-
inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines …
inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines …
Different barbiturate derivatives linked to aryl hydrazone moieties as urease inhibitors; design, synthesis, urease inhibitory evaluations, and molecular dynamic …
New series of barbiturates linked to aryl hydrazone derivatives 4a-n were designed and
synthesized. Briefly, aniline derivatives in the presence of HBF4 and NaNO2 convert to aryl …
synthesized. Briefly, aniline derivatives in the presence of HBF4 and NaNO2 convert to aryl …
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti …
FPD Viegas, M de Freitas Silva, MD da Rocha… - European Journal of …, 2018 - Elsevier
A new series of sixteen multifunctional N-benzyl-piperidine-aryl-acylhydrazones hybrid
derivatives was synthesized and evaluated for multi-target activities related to Alzheimer's …
derivatives was synthesized and evaluated for multi-target activities related to Alzheimer's …
Synthesis of benzo [d] thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents
A series of new benzo [d] thiazole-hydrazones were synthesized and characterized by
analytical and spectroscopic techniques. All the compounds were screened for their in vitro …
analytical and spectroscopic techniques. All the compounds were screened for their in vitro …
Dehydropeptide-based plasmonic magnetogels: A supramolecular composite nanosystem for multimodal cancer therapy
SRS Veloso, JA Martins, L Hilliou… - Journal of materials …, 2020 - pubs.rsc.org
Supramolecular hydrogels are highly promising candidates as biomedical materials owing
to their wide array of properties, which can be tailored and modulated. Additionally, their …
to their wide array of properties, which can be tailored and modulated. Additionally, their …
Novel dehydropeptide-based magnetogels containing manganese ferrite nanoparticles as antitumor drug nanocarriers
SRS Veloso, CAB Magalhães… - Physical Chemistry …, 2019 - pubs.rsc.org
Herein, novel dehydropeptide-based magnetogels, based on the hydrogelators Npx-L-Phe-
Z-ΔAbu-OH, Npx-L-Trp-Z-ΔPhe-OH and Npx-L-Ala-Z-ΔPhe-Gly-L-Arg-Gly-L-Asp-Gly-OH and …
Z-ΔAbu-OH, Npx-L-Trp-Z-ΔPhe-OH and Npx-L-Ala-Z-ΔPhe-Gly-L-Arg-Gly-L-Asp-Gly-OH and …
[HTML][HTML] Identification of novel diclofenac acid and naproxen bearing hydrazones as 15-LOX inhibitors: Design, synthesis, in vitro evaluation, cytotoxicity, and in silico …
A Sardar, S Daud, BA Shah, W Shahid, M Ashraf… - Arabian Journal of …, 2022 - Elsevier
Inflammation is the immune system's adaptive response to tissue dysfunction or homeostatic
imbalance, inducing fever, pain, physiological and biochemical changes via the …
imbalance, inducing fever, pain, physiological and biochemical changes via the …
[HTML][HTML] Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes
PA Elzahhar, R Orioli, NW Hassan, S Gobbi… - European Journal of …, 2024 - Elsevier
As a new approach to the management of inflammatory disorders, a series of chromone-
based derivatives containing a (carbamate) hydrazone moiety was designed and …
based derivatives containing a (carbamate) hydrazone moiety was designed and …
New small-molecule analgesics
SS Laev, NF Salakhutdinov - Current Medicinal Chemistry, 2021 - ingentaconnect.com
Pain is a symptom of ninety percent of human diseases, and pain management is a very
important medicinal problem. Various modulators of the pain response have been detected …
important medicinal problem. Various modulators of the pain response have been detected …