Aggregatibacter actinomycetemcomitans (Aa) is a low-abundance Gram-negative oral
pathobiont that is highly associated with a silent but aggressive orphan disease that results …

Advancements in DNA sequencing technologies within the last decade have stimulated an
unprecedented interest in the human microbiome, largely due the broad diversity of human …

Essential genes encode the processes that are necessary for life. Until recently, commonly
applied binary classifications left no space between essential and non-essential genes. In …

Transposon mutagenesis coupled with next-generation DNA sequencing (Tn-seq) is a
powerful tool for discovering regions of the genome that are required for the survival of …

The Group A Streptococcus remains a significant human pathogen causing a wide array of
disease ranging from self-limiting to life-threatening invasive infections. Epithelium (skin or …

Aggregatibacter actinomycetemcomitans, the focus of this review, was initially proposed as a
microbe directly related to a phenotypically distinct form of periodontitis called localized …

Haemophilus parainfluenzae (Hp) is a Gram-negative, highly prevalent, and abundant
commensal in the human oral cavity, and an infrequent extraoral opportunistic pathogen. Hp …

The human oral microbial community has been considered a reservoir of antibiotic
resistance. Currently, the effects of periodontitis and the scaling and root planing (SRP) …

Coxiella burnetii is an intracellular pathogen responsible for causing Q fever in humans, a
disease with varied presentations ranging from a mild flu-like sickness to a debilitating …

Aggregatibacter actinomycetemcomitans, a Gram‐negative oral pathobiont causing
aggressive periodontitis and systemic infections, demonstrates serum resistance. We have …