An active targeting strategy-enabled DNA tetrahedron delivery vehicle could facilitate stable
drug encapsulation and stimuli-responsive on-demand release, building a universal …

Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …

The physicochemical nature of DNA allows the assembly of highly predictable structures via
several fabrication strategies, which have been applied to make breakthroughs in various …

Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …

The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …

DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Deoxyribonucleic acid (DNA) stores genetic information as a biomolecule, and also is
regarded as a block copolymer and polyanion. Under favorable environments, DNA …