1Department of Cardiology, Division of Electrophysiology, University Heart Center Zurich,
Switzerland; 2Age-Related Health Care, Tallaght University Hospital/Department of …

Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

The current manuscript is the second update of the original Practical Guide, published in
2013 [Heidbuchel et al. European Heart Rhythm Association Practical Guide on the use of …

Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …

Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …

The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …

Understanding the natural history of and factors associated with pharmacoresistant epilepsy
provides the foundation for formulating mechanistic hypotheses that can be evaluated to …

Epilepsy, a common multifactorial neurological disease, affects about 69 million people
worldwide constituting nearly 1% of the world population. Despite decades of extensive …

Acquired resistance during cancer treatment is unfortunately a frequent event. There are
several reasons for this, including the ability of the ATP-binding cassette transporters (ABC …

Neurodegenerative disorders including Alzheimer's, Parkinson's, and dementia are chronic
and advanced diseases that are associated with loss of neurons and other related …