The concept of diffusion magnetic resonance (MR) imaging emerged in the mid-1980s,
together with the first images of water diffusion in the human brain, as a way to probe tissue …

Important advances have been made in the understanding and management of adult
gliomas and primary CNS lymphomas—the two most common primary brain tumours …

Background For virtually every patient with colorectal cancer (CRC), hematoxylin–eosin
(HE)–stained tissue slides are available. These images contain quantitative information …

Dynamic contrast‐enhanced MRI (DCE‐MRI) is a functional MRI method where T1‐
weighted MR images are acquired dynamically after bolus injection of a contrast agent. The …

It remains difficult to distinguish tumor recurrence from radiation necrosis after brain tumor
therapy. Here we show that these lesions can be distinguished using the amide proton …

Perfusion is a fundamental biological function that refers to the delivery of oxygen and
nutrients to tissue by means of blood flow. Perfusion MRI is sensitive to microvasculature …

Neuroimaging enables the noninvasive evaluation of glioma and is considered to be one of
the key factors for individualized therapy and patient management, since accurate diagnosis …

Hematoxylin and eosin-stained biopsy slides are regularly available for colorectal cancer
patients. These slides are often not used to define objective biomarkers for patient …

Glioblastoma multiforme (GBM), which account for more than 50% of all gliomas, is among
the deadliest of all human cancers. Given the dismal prognosis of GBM, it would be …

Neurologists nowadays no longer view neurodegenerative diseases, like Parkinson's and
Alzheimer's disease, as single entities, but rather as a spectrum of multifaceted symptoms …