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A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …

The field of medicine is moving toward the use of biomarkers for the optimization of
individualized care. This is a particular challenge for the field of psychiatry, in which …

Advances in brain imaging techniques have allowed neurobiological research to temporally
analyze signals coding for the anticipation of reward. In addicted populations, both …

Background Previous voxel-based morphometric (VBM) and functional magnetic resonance
imaging (fMRI) studies have shown changes in brain structure and function in cocaine …

Importance Individuals with cocaine use disorder (CUD) have difficulty monitoring ongoing
behavior, possibly stemming from dysfunction of brain regions mediating insight and self …

Characterizing developmental changes in frontostriatal circuitry is critical to understanding
adolescent development and can clarify neurobiological mechanisms underlying increased …

Learned habitual responses to environmental stimuli allow efficient interaction with the
environment, freeing cognitive resources for more demanding tasks. However, when the …

Background Nearly half of individuals with substance use disorders relapse in the year after
treatment. A diagnostic tool to help clinicians make decisions regarding treatment does not …

Different drugs of abuse impact the morphology of fronto-striatal dopaminergic targets in
both common and unique ways. While dorsal striatal volume tracks with addiction severity …