Components from venoms have stimulated many drug discovery projects, with some notable
successes. These are briefly reviewed, from captopril to ziconotide. However, there have …

In the 30 years since the identification of the natriuretic peptides, their involvement in
regulating fluid and blood pressure has become firmly established. Data indicating a role for …

Natriuretic peptides (NPs) are a group of peptide-hormones mainly secreted from the heart,
signaling via c-GMP coupled receptors. NP are well known for their renal and cardiovascular …

Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of
them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic …

Since the discovery of natriuretic peptides (NPs) by de Bold et al. in 1981, the cardiovascular
community has been well aware that they exert potent effects on vessels, heart remodeling …

The incidence of heart failure with preserved ejection fraction (HFpEF) is increasing and its
challenging diagnosis and management combines clinical, imagistic and biological data …

Natriuretic peptides are cardiac-derived hormones with a range of protective functions,
including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved …

The cardiac hormone atrial natriuretic peptide (ANP) is critically involved in the maintenance
of arterial blood pressure and intravascular volume homeostasis. Its cGMP‐producing GC‐A …

Despite considerable therapeutic advances, heart failure remains a medical and
socioeconomic problem. Thus, there is a compelling need for new drugs that could improve …

C-type natriuretic peptide (CNP) represents the 'local'member of the natriuretic peptide
family, functioning in an autocrine or paracrine capacity to modulate a hugely diverse …