HIV‐1 neutralizing antibodies: understanding nature's pathways
JR Mascola, BF Haynes - Immunological reviews, 2013 - Wiley Online Library
The development of an effective vaccine has been hindered by the enormous diversity of
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …
Trichomoniasis and HIV interactions: a review
P Kissinger, A Adamski - Sexually transmitted infections, 2013 - sti.bmj.com
Objective To discuss the epidemiology of Trichomonas vaginalis (TV) and HIV co-infections,
the role of TV in acquisition and transmission of HIV, special treatment considerations for TV …
the role of TV in acquisition and transmission of HIV, special treatment considerations for TV …
Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
While several clinical studies have shown that HIV-1 infection is associated with increased
permeability of the intestinal tract, there is very little understanding of the mechanisms …
permeability of the intestinal tract, there is very little understanding of the mechanisms …
Understanding and learning from the success of prophylactic human papillomavirus vaccines
JT Schiller, DR Lowy - Nature Reviews Microbiology, 2012 - nature.com
An estimated 5% of human cancers are caused by human papillomavirus (HPV) infections,
and most of these cancers are of the cervix. Two prophylactic HPV vaccines that target the …
and most of these cancers are of the cervix. Two prophylactic HPV vaccines that target the …
The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
C Cicala, E Martinelli, JP McNally… - Proceedings of the …, 2009 - National Acad Sciences
Both activated and resting CD4+ T cells in mucosal tissues play important roles in the
earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient …
earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient …
[HTML][HTML] Induction of immunity to human immunodeficiency virus type-1 by vaccination
MJ McElrath, BF Haynes - Immunity, 2010 - cell.com
Recent findings have brought optimism that development of a successful human
immunodeficiency virus type-1 (HIV-1) vaccine lies within reach. Studies of early events in …
immunodeficiency virus type-1 (HIV-1) vaccine lies within reach. Studies of early events in …
Vaginal concentrations of lactic acid potently inactivate HIV
M Aldunate, D Tyssen, A Johnson… - Journal of …, 2013 - academic.oup.com
Abstract Objectives When Lactobacillus spp. dominate the vaginal microbiota of women of
reproductive age they acidify the vagina to pH< 4.0 by producing∼ 1% lactic acid in a nearly …
reproductive age they acidify the vagina to pH< 4.0 by producing∼ 1% lactic acid in a nearly …
HIV-1 gp120 induces TLR2-and TLR4-mediated innate immune activation in human female genital epithelium
A Nazli, JK Kafka, VH Ferreira, V Anipindi… - The Journal of …, 2013 - journals.aai.org
Although women constitute half of all HIV-1–infected people worldwide (UNAIDS World
AIDS Day Report, 2011), the earliest events in the female reproductive tract (FRT) during …
AIDS Day Report, 2011), the earliest events in the female reproductive tract (FRT) during …
[HTML][HTML] Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus
LA Lagenaur, BE Sanders-Beer, B Brichacek, R Pal… - Mucosal …, 2011 - Elsevier
Most human immunodeficiency virus (HIV) transmissions in women occur through the
cervicovaginal mucosa, which is coated by a bacterial biofilm including Lactobacillus. This …
cervicovaginal mucosa, which is coated by a bacterial biofilm including Lactobacillus. This …
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7
Sexual transmission of human immunodeficiency virus type 1 (HIV-1) most often results from
productive infection by a single transmitted/founder (T/F) virus, indicating a stringent …
productive infection by a single transmitted/founder (T/F) virus, indicating a stringent …