The dormant blood microbiome in chronic, inflammatory diseases
Blood in healthy organisms is seen as a 'sterile'environment: it lacks proliferating microbes.
Dormant or not-immediately-culturable forms are not absent, however, as intracellular …
Dormant or not-immediately-culturable forms are not absent, however, as intracellular …
Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …
natural competition for the metal between bacterial pathogens and their human or animal …
Iron Acquisition in Mycobacterium tuberculosis
The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …
Bacterial ABC transporters of iron containing compounds
P Delepelaire - Research in microbiology, 2019 - Elsevier
Iron acquisition is an essential aspect of cell physiology for most bacteria. Although much is
known about how bacteria initially recognize the various iron sources they can encounter …
known about how bacteria initially recognize the various iron sources they can encounter …
A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis
Iron is essential for growth of Mycobacterium tuberculosis, the causative agent of
tuberculosis. To acquire iron from the host, M. tuberculosis uses the siderophores called …
tuberculosis. To acquire iron from the host, M. tuberculosis uses the siderophores called …
A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa
Q Perraud, L Moynié, V Gasser, M Munier… - ACS chemical …, 2018 - ACS Publications
Enterobactin (ENT) is a siderophore (iron-chelating compound) produced by Escherichia
coli to gain access to iron, an indispensable nutrient for bacterial growth. ENT is used as an …
coli to gain access to iron, an indispensable nutrient for bacterial growth. ENT is used as an …
Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter
Z Wang, W Hu, H Zheng - Biophysical Journal, 2020 - cell.com
To obtain essential metal ions, human pathogens secrete virulence-associated
siderophores at first and then retake the metal-chelated siderophores through a subfamily of …
siderophores at first and then retake the metal-chelated siderophores through a subfamily of …
Microbial siderophore-based iron assimilation and therapeutic applications
Siderophores are structurally diverse, complex natural products that bind metals with
extraordinary specificity and affinity. The acquisition of iron is critical for the survival and …
extraordinary specificity and affinity. The acquisition of iron is critical for the survival and …
Stenotrophomonas maltophilia produces an EntC-dependent catecholate siderophore that is distinct from enterobactin
MY Nas, NP Cianciotto - Microbiology, 2017 - microbiologyresearch.org
Stenotrophomonas maltophilia, a Gram-negative, multi-drug-resistant bacterium, is
increasingly recognized as a key opportunistic pathogen. Thus, we embarked upon an …
increasingly recognized as a key opportunistic pathogen. Thus, we embarked upon an …
Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands
MC Clifton, PB Rupert, TM Hoette, KN Raymond… - Journal of Structural …, 2019 - Elsevier
Abstract Siderocalin/Lipocalin 2/Neutrophil Gelatinase Associated Lipocalin/24p3 is an
innate immune system protein with bacteriostatic activity, acting by tightly binding and …
innate immune system protein with bacteriostatic activity, acting by tightly binding and …