Modeling dynamics in diseased cardiac tissue: Impact of model choice

TA Gokhale, E Medvescek… - Chaos: An Interdisciplinary …, 2017 - pubs.aip.org
Cardiac arrhythmias have been traditionally simulated using continuous models that
assume tissue homogeneity and use a relatively large spatial discretization. However, it is …

Simulation of ectopic pacemakers in the heart: multiple ectopic beats generated by reentry inside fibrotic regions

B Gouvêa de Barros… - BioMed research …, 2015 - Wiley Online Library
The inclusion of nonconducting media, mimicking cardiac fibrosis, in two models of cardiac
tissue produces the formation of ectopic beats. The fraction of nonconducting media in …

[HTML][HTML] Homogenisation for the monodomain model in the presence of microscopic fibrotic structures

BAJ Lawson, RW Dos Santos, IW Turner… - … in Nonlinear Science …, 2023 - Elsevier
Computational models in cardiac electrophysiology are notorious for long runtimes,
restricting the numbers of nodes and mesh elements in the numerical discretisations used …

[HTML][HTML] Graph-based homogenisation for modelling cardiac fibrosis

ME Farquhar, K Burrage, RW Dos Santos… - Journal of …, 2022 - Elsevier
Fibrosis, the excess of extracellular matrix, can affect, and even block, propagation of action
potential in cardiac tissue. This can result in deleterious effects on heart function, but the …

Simulations of Complex and Microscopic Models of Cardiac Electrophysiology Powered by Multi‐GPU Platforms

B Gouvêa de Barros, R Sachetto Oliveira… - … methods in medicine, 2012 - Wiley Online Library
Key aspects of cardiac electrophysiology, such as slow conduction, conduction block, and
saltatory effects have been the research topic of many studies since they are strongly related …

Mind the Gap: A semicontinuum model for discrete electrical propagation in cardiac tissue

CM Costa, PAA Silva… - IEEE Transactions on …, 2015 - ieeexplore.ieee.org
Electrical propagation in cardiac tissue is a discrete or discontinuous phenomenon that
reflects the complexity of the anatomical structures and their organization in the heart, such …

Multiparameter optimization of nonuniform passive diffusion properties for creating coarse-grained equivalent models of cardiac propagation

É Irakoze, V Jacquemet - Computers in biology and medicine, 2021 - Elsevier
The arrhythmogenic role of discrete cardiac propagation may be assessed by comparing
discrete (fine-grained) and equivalent continuous (coarse-grained) models. We aim to …

Simulation du remodelage structurel des oreillettes: dissociation endo-épicardique, optimisation multi-paramètre des conductivités et morphologie des potentiels …

E Irakoze - 2022 - papyrus.bib.umontreal.ca
La fibrillation auriculaire (FA) est le type d'arythmie cardiaque le plus fréquent. Cependant,
ses mécanismes sont encore mal compris et le développement de stratégies thérapeutiques …

Augmentations Vs. Restoration: A Computational Study of the Effects of Bacterial Sodium Channels on Cardiac Conduction

DA Needs - 2022 - search.proquest.com
Cardiac arrhythmias, including ventricular tachycardia, ventricular fibrillation, and atrial
fibrillation, are associated with ectopic triggers such as those resulting from …

Bridging Scales: How Microstructural Features Impact Macroscopic Cardiac Propagation

TA Gokhale - 2018 - search.proquest.com
Cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia are closely
associated with microscopic fibrotic changes in cardiac structure that result in a …