The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

Alpha-synuclein (aSyn) is a central player in Parkinson's disease (PD) but the precise
molecular mechanisms underlying its pathogenicity remain unclear. It has recently been …

A better understanding of the molecular and cellular determinants that influence the
pathology of Parkinson's disease (PD) is essential for developing effective diagnostic …

Abstract α-Synuclein is an abundant protein at the neuronal synapse that has been
implicated in Parkinson's disease for over 25 years and characterizes the hallmark …

Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation
of alpha-synuclein (aSyn) within neurons in the brain. Predominately pre-synaptic, aSyn has …

A great deal must still be learnt on the structural features of amyloid assemblies, particularly
prefibrillar aggregates, and the relationship of the latter with amyloid cytotoxicity. Presently, it …

Amyloid diseases display the presence, in targeted tissues and organs, of fibrillar deposits of
specific peptides or proteins. Increasing efforts are presently spent in investigating the …

Synucleinopathies are a group of neurodegenerative diseases with common pathological
lesions associated with the excessive accumulation and abnormal intracellular deposition of …