This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Morphine is an analgesic widely used to alleviate cancer pain. In addition, the perioperative
management of pain in cancer surgery patients most often includes opioids. However, there …

Study Design. Retrospective, economic analysis. Objective. To study patient profile
associated with preoperative chronic opioid therapy (COT), and study COT as a risk factor …

Aging is associated with a progressive loss of function in all organs. Under normal
conditions the physiologic compensation for age-related deficits is sufficient, but during …

Morphine is considered the “gold standard” for relieving pain and is currently one of the most
effective drugs available clinically for the management of severe pain associated with …

Opioid receptors are expressed on peripheral sensory nerve endings, cutaneous cells, and
immune cells; and local application of opioids is used for the treatment of inflammatory pain …

Methods: Mice received different doses of remifentanil over 30 or 60 min. The authors
assessed thermal (Hargreaves) and mechanical hyperalgesia (von Frey) at 2, 4, 7, and 10 …

Morphine is considered a highly potent analgesic agent used to relieve suffering of patients
with cancer. Several in vitro and in vivo studies showed that morphine also modulates …

Patients prescribed morphine for the management of chronic pain, and chronic heroin
abusers, often present with complications such as increased susceptibility to opportunistic …

Endothelial progenitor cells (EPC s), which can be cultured in vitro from mononuclear cells
in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial …