Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

Colorectal cancer (CRC) is a common malignancy and the fourth leading cause of cancer
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …

Background Colorectal cancer (CRC) is often diagnosed in advanced stages. Circulating
tumour DNA (ctDNA) has been proposed as an early diagnostic biomarker. However, as a …

Colorectal cancer (CRC) is a major cause of cancer death worldwide. CRC has poor
prognosis and there is a crucial need for new diagnostic and prognostic biomarkers to avoid …

Background The presence of cancer-specific DNA methylation patterns in epithelial
colorectal cells in human feces provides the prospect of a simple, non-invasive screening …

Aim Improved methods for early detection of colorectal cancer (CRC) are essential for
increasing survival. Hypermethylated DNA in blood or stool has been proposed as a …