[HTML][HTML] Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications

D Kouroupis, D Correa - Frontiers in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …

[HTML][HTML] Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery

SM Willerth, SE Sakiyama-Elbert - StemJournal, 2019 - content.iospress.com
Combining stem cells with biomaterial scaffolds serves as a promising strategy for
engineering tissues for both in vitro and in vivo applications. This updated review details …

Hydrogel mechanics are a key driver of bone formation by mesenchymal stromal cell spheroids

J Whitehead, KH Griffin, M Gionet-Gonzales… - Biomaterials, 2021 - Elsevier
Mesenchymal stromal cells (MSCs) can promote tissue repair in regenerative medicine, and
their therapeutic potential is further enhanced via spheroid formation. Stress relaxation of …

Fabrication techniques of biomimetic scaffolds in three‐dimensional cell culture: A review

AK Badekila, S Kini, AK Jaiswal - Journal of cellular physiology, 2021 - Wiley Online Library
In the last four decades, several researchers worldwide have routinely and meticulously
exercised cell culture experiments in two‐dimensional (2D) platforms. Using traditionally …

Engineered Cell‐Secreted Extracellular Matrix Modulates Cell Spheroid Mechanosensing and Amplifies Their Response to Inductive Cues for the Formation of …

T Gonzalez‐Fernandez, AJ Tenorio… - Advanced …, 2022 - Wiley Online Library
The clinical translation of mesenchymal stromal cell (MSC)‐based therapies remains
challenging due to rapid cell death and poor control over cell behavior. Compared to …

Mesenchymal stem cell spheroids embedded in an injectable thermosensitive hydrogel: an in situ drug formation platform for accelerated wound healing

MA Nilforoushzadeh, M Khodadadi Yazdi… - ACS biomaterials …, 2020 - ACS Publications
The ability of mesenchymal stem cells (MSCs) to enhance cutaneous wound healing has
been well established. Extensive expansion of cells to reach sufficient cell numbers for …

[HTML][HTML] Mesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration

H Kim, C Bae, YM Kook, WG Koh, K Lee… - Stem cell research & …, 2019 - Springer
Mesenchymal stem cell (MSC) encapsulation technique has long been emerged in tissue
engineering as it plays an important role in implantation of stem cells to regenerate a …

[HTML][HTML] Hydrogel degradation promotes angiogenic and regenerative potential of cell spheroids for wound healing

VL Thai, DH Ramos-Rodriguez, M Mesfin, JK Leach - Materials Today Bio, 2023 - Elsevier
Chronic nonhealing wounds are debilitating and diminish one's quality of life, necessitating
the development of improved strategies for effective treatment. Biomaterial-and cell-based …

Multifactorial experimental design to optimize the anti-inflammatory and proangiogenic potential of mesenchymal stem cell spheroids

KC Murphy, J Whitehead, PC Falahee, D Zhou… - Stem Cells, 2017 - academic.oup.com
Mesenchymal stem cell therapies promote wound healing by manipulating the local
environment to enhance the function of host cells. Aggregation of mesenchymal stem cells …

Alginate microspheres-collagen hydrogel, as a novel 3D culture system, enhanced skin wound healing of hUCMSCs in rats model

Y Gao, Y Kang, T Wang, C Li, S Shen, C Qu… - Colloids and Surfaces B …, 2022 - Elsevier
While stem cell transplantation has emerged as a promising approach to improving wound
healing outcomes, the application of stem cells to date has been limited by the poor survival …