Metaplasia: tissue injury adaptation and a precursor to the dysplasia–cancer sequence
V Giroux, AK Rustgi - Nature Reviews Cancer, 2017 - nature.com
Metaplasia is the replacement of one differentiated somatic cell type with another
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …
Modeling human digestive diseases with CRISPR-Cas9–modified organoids
Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells
as organoids that display structural and phenotypic features of healthy and diseased …
as organoids that display structural and phenotypic features of healthy and diseased …
Environment factors, DNA methylation, and cancer
J Liu, B Huang, F Ding, Y Li - Environmental Geochemistry and Health, 2023 - Springer
Today, the rapid development of science and technology and the rapid change in economy
and society are changing the way of life of human beings and affecting the natural, living …
and society are changing the way of life of human beings and affecting the natural, living …
Etiology, cancer stem cells and potential diagnostic biomarkers for esophageal cancer
K Liu, T Zhao, J Wang, Y Chen, R Zhang, X Lan, J Que - Cancer letters, 2019 - Elsevier
Esophageal cancer (EC) has been a leading cause of cancer death worldwide in part due to
late detection and lack of precision treatment. EC includes two major malignancies …
late detection and lack of precision treatment. EC includes two major malignancies …
Methylation panel is a diagnostic biomarker for Barrett's oesophagus in endoscopic biopsies and non-endoscopic cytology specimens
H Chettouh, O Mowforth, N Galeano-Dalmau… - Gut, 2018 - gut.bmj.com
Objective Barrett's oesophagus is a premalignant condition that occurs in the context of
gastro-oesophageal reflux. However, most Barrett's cases are undiagnosed because of …
gastro-oesophageal reflux. However, most Barrett's cases are undiagnosed because of …
Molecular landscape of esophageal cancer: implications for early detection and personalized therapy
Esophageal cancer (EC) is one of the most lethal cancers and a public health concern
worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous …
worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous …
Epigenetic biomarkers in esophageal cancer
AM Kaz, WM Grady - Cancer letters, 2014 - Elsevier
The aberrant DNA methylation of tumor suppressor genes is well documented in
esophageal cancer, including adenocarcinoma (EAC) and squamous cell carcinoma …
esophageal cancer, including adenocarcinoma (EAC) and squamous cell carcinoma …
NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in Colorectal Cancer
Y Luo, AM Kaz, S Kanngurn, P Welsch, SM Morris… - PLoS …, 2013 - journals.plos.org
NTRK3 is a member of the neurotrophin receptor family and regulates cell survival. It
appears to be a dependence receptor, and thus has the potential to act as an oncogene or …
appears to be a dependence receptor, and thus has the potential to act as an oncogene or …
Genetic and epigenetic alterations in Barrett's esophagus and esophageal adenocarcinoma
AM Kaz, WM Grady, MD Stachler… - Gastroenterology …, 2015 - gastro.theclinics.com
Genetic and Epigenetic Alterations in Barrett’s Esophagus and Esophageal Adenocarcinoma -
Gastroenterology Clinics Skip to Main Content Skip to Main Menu Advertisement …
Gastroenterology Clinics Skip to Main Content Skip to Main Menu Advertisement …
Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy
M Schmidt, RJ Hackett, AM Baker… - Nature Reviews …, 2022 - nature.com
Cancer development is a dynamic evolutionary process characterized by marked
intratumoural heterogeneity at the genetic, epigenetic and phenotypic levels. Barrett …
intratumoural heterogeneity at the genetic, epigenetic and phenotypic levels. Barrett …