The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

The modern rise in obesity and its strong association with insulin resistance and type 2
diabetes have elicited interest in the underlying mechanisms of these pathologies. The …

Obesity is reaching epidemic proportions globally and represents a major cause of
comorbidities, mostly related to cardiovascular disease. The autonomic nervous system …

Fibroblast growth factor 21 (FGF21) is a metabolic regulator that provides efficient and
durable glycemic and lipid control in various animal models. However, its potential to treat …

Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential …

Maintaining the high standards that made the previous editions such well-respected and
widely used references, Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition …

We review mechanisms that regulate production of glucose by the liver, focusing on areas of
budding consensus, and endeavoring to provide a candid assessment of lingering …

Starch is the major glycemic carbohydrate in foods, and its nutritional property is related to
its rate and extent of digestion and absorption in the small intestine. A classification of starch …

Food intake and energy expenditure are controlled by complex, redundant, and distributed
neural systems that reflect the fundamental biological importance of adequate nutrient …

Under physiological conditions, the brain consumes over 20% of the whole body energy
supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries …