Rescue from replication stress during mitosis
M Fragkos, V Naim - Cell cycle, 2017 - Taylor & Francis
Genomic instability is a hallmark of cancer and a common feature of human disorders,
characterized by growth defects, neurodegeneration, cancer predisposition, and aging …
characterized by growth defects, neurodegeneration, cancer predisposition, and aging …
Anaphase bridges: not all natural fibers are healthy
A Finardi, LF Massari, R Visintin - Genes, 2020 - mdpi.com
At each round of cell division, the DNA must be correctly duplicated and distributed between
the two daughter cells to maintain genome identity. In order to achieve proper chromosome …
the two daughter cells to maintain genome identity. In order to achieve proper chromosome …
A mechanism for controlled breakage of under-replicated chromosomes during mitosis
While DNA replication and mitosis occur in a sequential manner, precisely how cells
maintain their temporal separation and order remains elusive. Here, we unveil a double …
maintain their temporal separation and order remains elusive. Here, we unveil a double …
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
PM Schoonen, F Talens, C Stok, E Gogola… - Nature …, 2017 - nature.com
Mutations in homologous recombination (HR) genes BRCA1 and BRCA2 predispose to
tumorigenesis. HR-deficient cancers are hypersensitive to Poly (ADP ribose)-polymerase …
tumorigenesis. HR-deficient cancers are hypersensitive to Poly (ADP ribose)-polymerase …
[HTML][HTML] Sequence and nuclease requirements for breakage and healing of a structure-forming (AT) n sequence within fragile site FRA16D
S Kaushal, CE Wollmuth, K Das, SE Hile, SB Regan… - Cell reports, 2019 - cell.com
Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human
metaphase chromosomes under replication stress and are often deleted in cancer cells. We …
metaphase chromosomes under replication stress and are often deleted in cancer cells. We …
Alternative lengthening of telomeres and mediated telomere synthesis
K Hou, Y Yu, D Li, Y Zhang, K Zhang, J Tong, K Yang… - Cancers, 2022 - mdpi.com
Simple Summary Alternative lengthing of telomere (ALT) is an important mechanism for
maintaining telomere length and cell proliferation in telomerase-negative tumor cells …
maintaining telomere length and cell proliferation in telomerase-negative tumor cells …
Expanded roles for the MutL family of DNA mismatch repair proteins
The MutL family of DNA mismatch repair proteins plays a critical role in excising and
repairing misincorporation errors during DNA replication. In many eukaryotes, members of …
repairing misincorporation errors during DNA replication. In many eukaryotes, members of …
Phosphorylation by CK2 regulates MUS81/EME1 in mitosis and after replication stress
A Palma, GM Pugliese, I Murfuni… - Nucleic acids …, 2018 - academic.oup.com
The MUS81 complex is crucial for preserving genome stability through the resolution of
branched DNA intermediates in mitosis. However, untimely activation of the MUS81 complex …
branched DNA intermediates in mitosis. However, untimely activation of the MUS81 complex …
Control of Mus81 nuclease during the cell cycle
DNA replication and homologous recombination involve the formation of branched DNA
structures that physically link chromosomes. Such DNA‐based connections, which arise …
structures that physically link chromosomes. Such DNA‐based connections, which arise …
Intricate SUMO-based control of the homologous recombination machinery
N Dhingra, X Zhao - Genes & development, 2019 - genesdev.cshlp.org
The homologous recombination (HR) machinery plays multiple roles in genome
maintenance. Best studied in the context of DNA double-stranded break (DSB) repair …
maintenance. Best studied in the context of DNA double-stranded break (DSB) repair …