Phosphorylated tau in Alzheimer's disease and other tauopathies
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
Protein kinase CK2: a potential therapeutic target for diverse human diseases
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …
substrates, controls several signaling pathways, and is implicated in a plethora of human …
Liquid-liquid phase separation induces pathogenic tau conformations in vitro
Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …
meet the biological requirement for spatiotemporal regulation of cellular components and …
Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in …
M Nakano, K Kubota, E Kobayashi, TS Chikenji… - Scientific reports, 2020 - nature.com
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We
previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) …
previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) …
Nicotinamide riboside—the current state of research and therapeutic uses
M Mehmel, N Jovanović, U Spitz - Nutrients, 2020 - mdpi.com
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …
[HTML][HTML] The neuropathology and neurobiology of traumatic brain injury
K Blennow, J Hardy, H Zetterberg - Neuron, 2012 - cell.com
The acute and long-term consequences of traumatic brain injury (TBI) have received
increased attention in recent years. In this Review, we discuss the neuropathology and …
increased attention in recent years. In this Review, we discuss the neuropathology and …
Cellular proteostasis in neurodegeneration
The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …
through a vast network of biochemical pathways. This requires the regulated control of …
Tau protein modifications and interactions: their role in function and dysfunction
A Mietelska-Porowska, U Wasik, M Goras… - International journal of …, 2014 - mdpi.com
Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …
and stabilization. It is predominantly associated with axonal microtubules and present at …
Mechanisms of protein toxicity in neurodegenerative diseases
Protein toxicity can be defined as all the pathological changes that ensue from
accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most …
accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most …
Axons matter: the promise of treating neurodegenerative disorders by targeting SARM1-mediated axonal degeneration
R Krauss, T Bosanac, R Devraj, T Engber… - Trends in …, 2020 - cell.com
Attempts to develop neuroprotective treatments for neurodegenerative disorders have not
yet been clinically successful. Axonal degeneration has been recognized as a predominant …
yet been clinically successful. Axonal degeneration has been recognized as a predominant …