Phosphorylated tau in Alzheimer's disease and other tauopathies

P Rawat, U Sehar, J Bisht, A Selman… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Protein kinase CK2: a potential therapeutic target for diverse human diseases

C Borgo, C D'Amore, S Sarno, M Salvi… - Signal transduction and …, 2021 - nature.com
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

NM Kanaan, C Hamel, T Grabinski, B Combs - Nature communications, 2020 - nature.com
Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in …

M Nakano, K Kubota, E Kobayashi, TS Chikenji… - Scientific reports, 2020 - nature.com
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We
previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) …

Nicotinamide riboside—the current state of research and therapeutic uses

M Mehmel, N Jovanović, U Spitz - Nutrients, 2020 - mdpi.com
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …

[HTML][HTML] The neuropathology and neurobiology of traumatic brain injury

K Blennow, J Hardy, H Zetterberg - Neuron, 2012 - cell.com
The acute and long-term consequences of traumatic brain injury (TBI) have received
increased attention in recent years. In this Review, we discuss the neuropathology and …

Cellular proteostasis in neurodegeneration

A Kurtishi, B Rosen, KS Patil, GW Alves… - Molecular neurobiology, 2019 - Springer
The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …

Tau protein modifications and interactions: their role in function and dysfunction

A Mietelska-Porowska, U Wasik, M Goras… - International journal of …, 2014 - mdpi.com
Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …

Mechanisms of protein toxicity in neurodegenerative diseases

CG Chung, H Lee, SB Lee - Cellular and Molecular Life Sciences, 2018 - Springer
Protein toxicity can be defined as all the pathological changes that ensue from
accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most …

Axons matter: the promise of treating neurodegenerative disorders by targeting SARM1-mediated axonal degeneration

R Krauss, T Bosanac, R Devraj, T Engber… - Trends in …, 2020 - cell.com
Attempts to develop neuroprotective treatments for neurodegenerative disorders have not
yet been clinically successful. Axonal degeneration has been recognized as a predominant …