As the intestinal microbiota has become better appreciated as necessary for maintenance of
physiologic homeostasis and also as a modulator of disease processes, there has been a …

Atopic dermatitis (AD) is a public health concern and is increasing in prevalence in urban
areas. Recent advances in sequencing technology have demonstrated that the development …

The microbiome modulates host immunity and aids the maintenance of tolerance in the gut,
where microbial and food-derived antigens are abundant. Yet modern dietary factors and …

There has been a striking generational increase in life-threatening food allergies in
Westernized societies,. One hypothesis to explain this rising prevalence is that twenty-first …

Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features
of Alzheimer's disease (AD). In addition to astrocyte and microglial reactivity, emerging …

The ontogeny and maturation of the immune system is modulated by the microbiota. During
fetal life, the mother's microbiota produces compounds that are transferred to the fetus and …

The mammalian intestine is colonized by trillions of microorganisms, most of which are
bacteria that have co-evolved with the host in a symbiotic relationship. The collection of …

The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to
allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to …

Dietary and bacterial metabolites influence immune responses. This raises the question
whether the increased incidence of allergies, asthma, some autoimmune diseases …

Although commensal bacteria are crucial in maintaining immune homeostasis of the
intestine, the role of commensal bacteria in immune responses at other mucosal surfaces …