Therapeutics of Alzheimer's disease: Past, present and future
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
Molecular basis of familial and sporadic Alzheimer's disease
J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …
(30%) causes. Among the genetic factors are genes associated with a family history of the …
Tau protein and its role in blood–brain barrier dysfunction
A Michalicova, P Majerova, A Kovac - Frontiers in molecular …, 2020 - frontiersin.org
The blood–brain barrier (BBB) plays a crucial role in maintaining the specialized
microenvironment of the central nervous system (CNS). In aging, the stability of the BBB …
microenvironment of the central nervous system (CNS). In aging, the stability of the BBB …
Role of environmental contaminants in the etiology of Alzheimer's disease: a review
M Yegambaram, B Manivannan… - Current Alzheimer …, 2015 - ingentaconnect.com
Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70%
risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include …
risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include …
[HTML][HTML] Meat consumption and risk of incident dementia: cohort study of 493,888 UK Biobank participants
Background Worldwide, the prevalence of dementia is increasing and diet as a modifiable
factor could play a role. Meat consumption has been cross-sectionally associated with …
factor could play a role. Meat consumption has been cross-sectionally associated with …
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …
successes in identifying three genes that cause early-onset familial AD (those that encode …
Natural products as a source of Alzheimer's drug leads
P Williams, A Sorribas, MJR Howes - Natural product reports, 2011 - pubs.rsc.org
Covering: up to 2010 This review focuses on recent developments in the use of natural
products as therapeutics for Alzheimer's disease. The compounds span a diverse array of …
products as therapeutics for Alzheimer's disease. The compounds span a diverse array of …
Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and …
J Wu, MR Basha, B Brock, DP Cox… - Journal of …, 2008 - Soc Neuroscience
The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may
drive AD pathogenesis; however, the triggering factors and the period of their action are …
drive AD pathogenesis; however, the triggering factors and the period of their action are …
Environmental-induced oxidative stress in neurodegenerative disorders and aging
L Migliore, F Coppedè - Mutation Research/Genetic Toxicology and …, 2009 - Elsevier
The aetiology of most neurodegenerative disorders is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. Free radicals derived …
interaction between environmental factors and genetic predisposition. Free radicals derived …
Epigenetics, oxidative stress, and Alzheimer disease
Alzheimer disease (AD) is a progressive neurodegenerative disorder whose clinical
manifestations appear in old age. The sporadic nature of 90% of AD cases, the differential …
manifestations appear in old age. The sporadic nature of 90% of AD cases, the differential …