Signals from the surrounding niche drive proliferation and suppress differentiation of
intestinal stem cells (ISCs) at the bottom of intestinal crypts. Among sub-epithelial support …

Single-cell nucleic acid analysis aims at discovering the genetic differences between
individual cells which is well known as the cellular heterogeneity. This technology facilitates …

The gut epithelium has a remarkable ability to recover from damage. We employed a
combination of high-throughput sequencing approaches, mouse genetics, and murine and …

Clostridioides difficile is a Gram-positive bacterium that can cause mild to severe diarrhea,
inflammation, and colonic tissue damage in animal hosts. Symptoms of the disease can be …

Gut inflammation involves contributions from immune and non-immune cells, whose
interactions are shaped by the spatial organization of the healthy gut and its remodeling …

The significant anatomical changes in large intestine of germ-free (GF) mice provide
excellent material for understanding microbe-host crosstalk. We observed significant …

In the last three decades, researchers have utilized genome engineering to alter the DNA
sequence in the living cells of a plethora of organisms, ranging from plants, fishes, mice, to …