The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Collagen provides mechanical and biological support for virtually all human tissues in the
extracellular matrix (ECM). Its defining molecular structure, the triple-helix, could be …

Background Cardiac fibrosis represents a key element in the pathophysiology of heart
failure with preserved ejection fraction (HFpEF), a condition highly prevalent amongst …

Despite major advances in acute interventions for myocardial infarction (MI), adverse
cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain …

Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

After an ischemic injury, the heart undergoes a complex process of structural and functional
remodeling that involves several steps, including inflammatory and fibrotic responses. In this …

The transforming growth factor beta (TGF-β) is a crucial cytokine that get increasing concern
in recent years to treat human diseases. This signal controls multiple cellular responses …

Macrophages sense changes in the extracellular matrix environment through the integrins
and play a central role in regulation of the reparative response after myocardial infarction …

Abstract Cardiomyocytes comprise∼ 70% to 85% of the total volume of the adult
mammalian heart but only about 25% to 35% of its total number of cells. Advances in single …