Although the seminal event in sickle cell disease is the polymerization of abnormal
hemoglobin, the downstream pathophysiology of vasoocclusion results from heterotypic …

Sickle cell disease (SCD) is a hematologic disorder with complex pathophysiology that
includes chronic hemolysis, vaso-occlusion and inflammation. Increased leukocyte …

Background: Blood cell aggregation and adherence to vascular endothelium and
inflammation play a central role in vaso-occlusive crisis in sickle cell disease. The …

The anemia of sickle cell disease is associated with a severe inflammatory vasculopathy
and endothelial dysfunction, which leads to painful and life-threatening clinical …

Abstract n-3 Polyunsaturated fatty acids (PUFAs) are organic acids, essential for mammals,
whose deficiency is associated with different diseases. The American Heart Association …

Blood cell membranes in sickle cell disease (SCD) have low docosahexaenoic acid (DHA).
DHA treatment reduces sickle cell crisis (SCC) rate and ameliorates the inflammation …

Chronic inflammation and reduced blood levels of omega-3 fatty acids (n− 3) are known
characteristics of sickle cell disease (SCD). The anti-inflammatory properties of n− 3 fatty …

Background Sickle cell disease (SCD) is a genetic hemoglobinopathy associated with high
morbidity and mortality. The primary cause of hospitalization in SCD is vaso‐occlusive crisis …

Nutritional research in sickle cell disease has been the focus in recent times owing to not
only specific nutritional deficiencies, but also the improvements associated with less painful …

Erythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts
of pro‐oxidants than normal cells. Oxidative stress seems to primarily affect the membrane …