Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

The two main types of diabetes mellitus have distinct etiologies, yet a similar outcome: loss
of islet β-cell function that is solely responsible for the secretion of the insulin hormone to …

Objective Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing
functions in regulating plasma glucose levels, the two cell types share a common …

One major unresolved question in the field of pancreas biology is whether ductal cells have
the ability to generate insulin-producing β-cells. Conclusive examination of this question has …

Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell
therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic …

Using a flow cytometry–based screen of commercial antibodies, we have identified cell-
surface markers for the separation of pancreatic cell types derived from human embryonic …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Pancreatic multipotent progenitor cells (MPCs) produce acinar, endocrine and duct cells
during organogenesis, but their existence and location in the mature organ remain …

Understanding the regulation of islet cell mass has important implications for the discovery
of regenerative therapies for diabetes. The liver plays a central role in metabolism and the …

Background Inability to control autoimmunity is the primary barrier to developing a cure for
type 1 diabetes (T1D). Evidence that human cord blood-derived multipotent stem cells (CB …