During chronic human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV)
infection prior to AIDS progression, the vast majority of viral replication is concentrated within …

There is a need to develop improved methods to treat and potentially cure HIV infection.
During chronic HIV infection, replication is concentrated within T follicular helper cells (Tfh) …

The advent of Transcription Activator-Like Effector Nucleases (TALENs), and similar
technologies such as CRISPR, provide a straightforward and cost effective option for …

Artemis is a hairpin-opening endonuclease involved in nonhomologous end-joining and V
(D) J recombination. Deficiency of Artemis results in radiation-sensitive severe combined …

Targeted gene therapy strategies utilizing homology-driven repair (HDR) allow for greater
control over transgene integration site, copy number, and expression—significant …

Artemis is a single-stranded endonuclease, deficiency of which results in a radiation-
sensitive form of severe combined immunodeficiency (SCID-A) most effectively treated by …

Artemis is an endonucleolytic enzyme involved in nonhomologous double-strand break
repair and V (D) J recombination. Deficiency of Artemis results in a B− T− radiosensitive …

Background Hematologic toxicity represents a major side effect of cytotoxic chemotherapy
frequently preventing adequately dosed chemotherapy application and impeding …

Ex vivo selection of transduced hematopoietic stem cells (HSC) with drug‐resistance genes
offers the possibility to enrich transduced cells prior to engraftment, toward increased …

Human embryonic stem cells (hESCs) provide a novel source of hematopoietic and other
cell populations suitable for gene therapy applications. Preclinical studies to evaluate …