The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …

Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

We review signaling by reactive oxygen species, which is emerging as a major physiological
process. However, among the reactive oxygen species, H2O2 best fulfills the requirements …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …

Since their discovery as a substrate for ribonucleotide reductase (RNR), the role of
thioredoxin (Trx) and glutaredoxin (Grx) has been largely extended through their regulatory …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

Paclitaxel is recommended as a first-line chemotherapeutic agent against ovarian cancer,
but drug resistance becomes a major limitation of its success clinically. The key molecule or …

Regulation of disulfide dithiol exchange has become increasingly important in our
knowledge of plant life. Initially discovered as regulators of light-dependent malate …

Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain
containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member …