Chemotherapy is currently one of the most effective ways to treat cancer. However,
traditional chemotherapy faces several obstacles to clinical trials, such as poor …

In this review glycosidase activated prodrugs that target cancer cells are discussed.
Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release …

The widespread use of molecular machines in biology has long suggested that great
rewards could come from bridging the gap between synthetic molecular systems and the …

Mechanically interlocked molecules, such as rotaxanes and catenanes, are receiving
increased attention as scaffolds for the development of new catalysts, driven by both their …

The field of mechanically interlocked molecules (MIMs) has advanced rapidly in recent
years, with much work focused on their use in materials, sensing, and catalysis. However …

The active template approach to interlocked molecules takes advantage of the ability of
metal ions to both organize precursor fragments for mechanical bond formation and to …

Interest in self-immolative chemistry has grown over the past decade with more research
groups harnessing the versatility to control the release of a compound from a larger …

The development of smart theranostic systems with favourable biocompatibility, high loading
efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal …

The active template synthesis of mechanically interlocked molecular architectures exploits
the dual ability of various structural elements (metals or, in the case of metal-free active …

Nature embeds some of its molecular machinery, including ion pumps, within lipid bilayer
membranes. This has inspired chemists to attempt to develop synthetic analogues to exploit …