Advances in the management of anaplastic thyroid carcinoma: transforming a life-threatening condition into a potentially treatable disease

I Califano, A Smulever, F Jerkovich, F Pitoia - Reviews in Endocrine and …, 2024 - Springer
Anaplastic thyroid cancer (ATC) is an infrequent thyroid tumor that usually occurs in elderly
patients. There is often a history of previous differentiated thyroid cancer suggesting a …

Novel inhibitor-based therapies for thyroid cancer—An update

M Ratajczak, D Gaweł, M Godlewska - International journal of molecular …, 2021 - mdpi.com
Thyroid cancers (TCs) are the most common tumors of the endocrine system and a constant
rise in the number of TC cases has been observed for the past few decades. TCs are one of …

Target therapy for BRAF mutated anaplastic thyroid cancer: a clinical and molecular study

TN da Silva, R Rodrigues, A Saramago… - European Journal of …, 2023 - academic.oup.com
Objectives Anaplastic thyroid carcinoma (ATC) has a poor survival. The combination of
Dabrafenib plus Trametinib (DT) had a significant impact in survival of BRAF p. V600E …

Spectrum of BRAF aberrations and its potential clinical implications: insights from integrative pan-cancer analysis

Q Yi, J Peng, Z Xu, Q Liang, Y Cai, B Peng… - … in Bioengineering and …, 2022 - frontiersin.org
B-Raf proto-oncogene serine/threonine-protein kinase (BRAF) is frequently altered in
multiple cancer types, and BRAF V600 mutations act as a prime target for precision therapy …

E-cadherin on epithelial–mesenchymal transition in thyroid cancer

X Zhu, X Wang, Y Gong, J Deng - Cancer Cell International, 2021 - Springer
Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck.
Recurrence, metastasis and high malignant expression after routine treatment are serious …

Rationale efficacy and safety evidence of lenvatinib and pembrolizumab association in anaplastic thyroid carcinoma

L Boudin, JB Morvan, J Thariat, D Métivier, PY Marcy… - Current …, 2022 - mdpi.com
Anaplastic thyroid carcinoma (ATC) are highly aggressive malignant tumors with poor
overall prognosis despite multimodal therapy. As ATC are extremely rare, no randomized …

Anaplastic thyroid cancer: Genome-based search for new targeted therapy options

DA Hescheler, MJM Hartmann… - Endocrine …, 2022 - ec.bioscientifica.com
Objective Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers with
meager treatment options. We aimed to identify the targeted drugs already approved by the …

Efficacy and safety of lenvatinib in anaplastic thyroid carcinoma: a meta-analysis

D Huang, J Zhang, X Zheng, M Gao - Frontiers in Endocrinology, 2022 - frontiersin.org
Background Lenvatinib has shown promising efficacy in targeted therapies that have been
tested to treat anaplastic thyroid carcinoma (ATC) in both preclinical and clinical studies. The …

Prognostic factors in radiotherapy of anaplastic thyroid carcinoma: a single center study over 31 years

J Jacob, D Vordermark, K Lorenz, D Medenwald - Radiation Oncology, 2023 - Springer
Background Anaplastic thyroid carcinoma has a very poor prognosis. We analyzed the effect
of surgery, radiotherapy and chemotherapy on survival time and side effects in patients with …

The role of targeted therapy and/or immunotherapy therapy in anaplastic thyroid carcinoma

G Wu, Y Song, S Yang, H Li, S Liu, L Gui, S Ni - Endocrine, 2024 - Springer
Background: Anaplastic thyroid carcinoma (ATC) is a highly invasive malignant tumor with a
poor prognosis. Traditional treatment methods have not been effective. However …